柴纬明

柴纬明   生物化学与分子生物学博士

副教授(校聘教授)，硕士生导师（学术型、专业型），博士生导师，江西省第二批高层次人才服务团成员（挂职乐安县副县长），江西省食品药品与粮食大类专指委成员，江西省科技特派员。

 ● 学习、工作经历：

2005.09-2009.07  江西师范大学半岛公司官方网站（广州）股份有限公司 理学学士（生物科学）

2009.09-2014.06  厦门大学半岛公司官方网站（广州）股份有限公司（硕博连读）理学博士（生物化学与分子生物学）

2014.07-2018.11  江西师范大学半岛公司官方网站（广州）股份有限公司 讲师

2018.12至今 江西师范大学半岛公司官方网站（广州）股份有限公司 副教授

2019.01-2011.12   江西师范大学半岛公司官方网站（广州）股份有限公司校聘教授

2022.03  至今抚州市乐安县副县长

 ●研究兴趣、领域：

食品科学与分子酶学（果蔬保鲜）、植物资源学和天然产物化学（植物天然产物活性成分分析和开发）、有机小分子合成及活性筛选

 ●开设的课程：

本科生课程：《植物生物学》、《植物生物学实验》、《植物生理学》

研究生课程：《植物成分分析》、《植物科学研究进展》

 ●代表性论文：

1. Chai W. M.,* Pan Q. X.,Bai Q. H., Wu Y. F.,Wei W. S., Wang L. J.,Zhu D. (2023). Condensed tannins from the leave of Dimocarpus longanLour. exhibit anti-tyrosinase, anti-melanogenesis,anti-browning, anti-α-glucosidase, and anti-glycation activities. Industrial crops and products.(SCI一区)

2.  Wen, Y., Zhang, Y., Zhang, X., Wang, L., Pan, Q., Bai, Q., ... &, Chai, W. M.*(2023). Inhibition of albendazole and 2‐(2‐aminophenyl)‐1 H‐benzimidazole against tyrosinase: mechanism, structure–activity relationship, and anti‐browning effect. Journal of the science of food and agriculture, 103(6), 2824-2837.(SCI二区)

3. Liang, Y. Q., Wen, Y. T., Fu, Q. Q., Yu, Z. Y., Wang, L. J., Zou, Z. R., ... & Chai, W. M.* (2022). Structure analysis and tyrosinase, melanogenesis, α-glucosidase, and nonenzymatic glycation inhibitory activities of polymeric proanthocyanidins from the pulp of Crataegus pinnatifida Bge. Industrial crops and products, 187, 115524.(SCI一区)

4. Yu, Z. Y., Xu, K., Wang, X., Wen, Y. T., Wang, L. J., Huang, D. Q., ... & Chai, W. M.* (2022). Punicalagin as a novel tyrosinase and melanin inhibitor: Inhibitory activity and mechanism. LWT, 161, 113318.(SCI一区)

5. 邓维良,柴纬明,^*罗麟霜.利巴韦林抗酪氨酸酶活性及其在贡梨中的保鲜应用[J].食品与发酵工业,2021,47(05):162-167.

6.  Song, S., Liu, Q., Chai, W. M.,^* Xia, S. S., Yu, Z. Y., & Wei, Q. M. (2021). Inhibitory potential of 4-hexylresorcinol against α-glucosidase and non-enzymatic glycation: Activity and mechanism. Journal of bioscience and bioengineering, 131(3), 241-249.

7. Chai, W. M.,^*Yu, Z. Y., Lin, M. Z., Wei, Q. M., & Song, S. (2021). 5-Methoxy-2-mercaptobenzimidazole as an efficient inhibitor on tyrosinase: Inhibitory activity and mechanism. Journal of bioscience and bioengineering, 131(4), 356-363.

8.  Ou-Yang, C., Chai, W. M,^*Xu, X., Song, S., Wei, Q., Huang, Q., & Zou, Z. (2020). Inhibitory potential of proanthocyanidins from the fruit pulp of Clausena lansium (Lour.) Skeels against α-glucosidase and non-enzymatic glycation: Activity and mechanism. Process biochemistry, 91, 364-373.

9.   Huang, Q., Chai, W. M.,^* Ma, Z. Y., Ou-Yang, C., Wei, Q. M., Song, S., ... & Peng, Y. Y. (2019). Inhibition of α-glucosidase activity and non-enzymatic glycation by tannic acid: Inhibitory activity and molecular mechanism. International journal of biological macromolecules,141，358-368. (SCI二区)

10. Chai, W. M.,^* Ou-Yang, C., Ma, Z., Song, S., Huang, Q., Wei, Q., & Peng, Y. (2019). Anti-α-glucosidase and antityrosinase activity of condensed tannins from the bark of Clausena lansium (Lour.) Skeels with antiproliferative and apoptotic properties in B16 mouse melanoma cells. Process biochemistry, 86, 205-214.

11. Chai, W. M. ,^*Wei, Q., Deng, W., Zheng, Y. , Chen, X., Huang, Q., Ou-Yang, C. and Peng, Y. Y. (2019). Anti-melanogenesis property of condensed tannins from Vigna angularis seed with potent antioxidant and DNA damage protection activities. Food function, 10(1), 99-111. (SCI一区)

12.  Lin, M. Z., Chai, W. M.,^* Zheng, Y. L., Huang, Q., Ou-Yang, C. (2019). Inhibitory kinetics and mechanism of rifampicin on α-glucosidase: Insights from spectroscopic and molecular docking analyses. International journal of biological macromolecules,122,1244-1252.(SCI二区)

13. Chai, W. M.,^* Huang, Q., Lin, M. Z., Ou-Yang, C., Huang, W. Y., Wang, Y. X., Xu, K. L., Feng, H. L. (2018). Condensed tannins from longan bark as inhibitor of tyrosinase: structure, activity, and mechanism. Journal of agricultural and food chemistry, 66(4), 908-917. (SCI一区)

14. Chai, W. M.,^*Ou-Yang, C., Huang, Q., Lin, M. Z., Wang, Y. X., Xu, K. L., (2018). Huang, W. Y., Pan, D. D. Antityrosinase and antioxidant properties of mung bean seed proanthocyanidins: Novel insights into the inhibitory mechanism. Food chemistry, 260, 27–36. (SCI一区)

15.  Lin, M. Z., Chai, W. M.,^* Ou-Yang, C., Huang, Q., Xu, X. H., Peng, Y. Y. (2018). Antityrosinase mechanism of omeprazole and its application on the preservation of fresh-cut Fuji apple. International journal of biological macromolecules,117, 538-545. (SCI二区)

16. Chai, W. M.,^* Lin, M. Z., Feng, H. L., Zou, Z. R., Wang, Y. X. (2017). Proanthocyanidins purified from fruit pericarp of Clausena lansium (Lour.) Skeels as efficient tyrosinase inhibitors: structure evaluation, inhibitory activity and molecular mechanism. Food function,8, 1043-1051. (SCI一区)

17. Chai, W. M.,^* Lin, M. Z., Wang, Y. X., Xu, K. L., Huang, W. Y., Pan, D. D., Zou Z R, & Peng, Y. Y. (2017). Inhibition of tyrosinase by cherimoya pericarp proanthocyanidins: Structural characterization, inhibitory activity and mechanism. Food research international, 100, 731-739. (SCI二区)

18. Chai, W. M.,^* Lin, M. Z., Song, F. J., Wang, Y. X., Xu, K. L., Huang, J. X., Fu, J. P., & Peng, Y. Y. (2017). Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism. International journal of biological macromolecules, 102, 425-430. (SCI二区)

19.  Wang, R., Chai, W. M.,^* Yang, Q., Wei, M. K., Peng, Y. Y.^*(2016). 2-(4-Fluorophenyl)-quinazolin-4 (3H)-one as a novel tyrosinase inhibitor: Synthesis, inhibitory activity, and mechanism. Bioorganic & medicinal chemistry, 24(19), 4620-4625.

20.  Wei, M. K., Chai W M,^* Wang, R., Yang, Q., Deng, Z., Peng, Y. Y.^* (2016). Quinazolinone derivatives: synthesis and comparison of inhibitory mechanisms on α-glucosidase. Bioorganic & medicinal chemistry. 25(4), 1303–1308

21. Chai, W. M.,^* Wei, M. K., Wang, R., Deng, R. G., Zou, Z. R., Peng, Y. Y. (2015). Avocado proanthocyanidins as source of tyrosinase inhibitors: structure characterization, inhibitory activity and mechanism. Journal of agricultural and food chemistry,63 (33), 7381–7387. (SCI一区)

22. Chai, W. M., Shi, Y, Feng, H. L., Xu, L., Xiang, Z. H., Gao, Y. S., Chen, Q. X.^*(2014). Structure characterization and anti-tyrosinase mechanism of polymeric proanthocyanidins fractionated from kiwifruit pericarp. Journal of agricultural and food chemistry,62(27), 6382-6389. (SCI一区)

23. Chai, W. M., Chen, C. M., Gao, Y. S., Feng, H. L., Ding, Y. M., Shi, Y., Zhou, H. T., Chen, Q. X.^*(2014). Structural analysis of proanthocyanidins isolated from fruit stone of Chinese hawthorn with potent antityrosinase and antioxidant activity. Journal of agricultural and food chemistry, 62(1), 123–129. (SCI一区)

24. Chai, W. M., Liu, X.,Hu, Y. H., Feng, H. L., Jia, Y. L., Guo, Y. J., Zhou, H. T.^*, Chen, Q. X.^*(2013).Antityrosinase and antimicrobial activities of furfuryl alcohol, furfural and furoic acid. International journal of biological macromolecules, 57, 151-155. (SCI二区)

25. Chai, W. M., Shi, Y., Feng, H. L., Qiu, L., Zhou, H. C., Deng, Z. W., Yan, C. L.^*, Chen, Q. X.^*(2012). NMR, HPLC-ESI-MS, and MALDI-TOF MS analysis of condensed tannins from Delonix regia and their bioactivities. Journal of agricultural and food chemistry, 60 (19), 5013-5022. (SCI一区)

  ● 科研项目：

1、国家自然科学基金：香豆素类化合物抗果蔬酶促褐变及抑菌机制研究（2021）主持

2、国家自然科学基金：龙眼（Dimocarpus longan Lour.）单宁分离鉴定与抗酪氨酸酶机理研究（2015） 主持

3、江西省自然科学基金--杰出青年基金项目：MALDI-TOF MS和UPLC-MS/MS指导分离壳斗科植物单宁（tannins）及其抗酪氨酸酶机制研究（2019）主持

4、江西省自然科学基金面上项目：山楂单宁的多样性强化及其抑制α－葡萄糖苷酶和非酶糖基化的分子机制（2023）主持

5、江西省自然科学基金青年项目：黄皮原花色素分离纯化、结构分析与抗α－葡萄糖苷酶机制研究（2017） 主持

 ●荣誉、奖励及参加学术团体的情况：

全国生命科学大赛全国一等奖（2022）、二等奖（2022）、三等奖（2023）

第十六届（2019）十八届（2023）“挑战杯”全国大学生课外学术科技作品竞赛江西省二等奖

江西植物学会青年教师优秀报告二等奖（2021）

江西省植物学会优秀论文二等奖（2018）

获福建省优秀论文三等奖、厦门市科技进步二等奖

江西师范大学熊智明奖教金

中国生物化学与分子生物学会会员

江西省植物学会会员

 ●联系方式：

地址： 江西省南昌市高新区江西师范大学半岛公司官方网站（广州）股份有限公司方荫楼3区W351室

mail：chaiweiming@jxnu.edu.cn,476239387@qq.com

电话：13755634408